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Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.
Göbel A. et al., J Bone Oncology, 2019; 16: 100237. Full publication.
SEMAPHORIN 4D is a soluble and membrane-bound protein
that plays important roles in physiologic processes such as vascular growth, tumor progression, and immune cell regulation.
Related literature:
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.
Lontos K et al., Front Endocrinol, 2018; 9:322. Full publication.
A high-sensitivity enzyme immunoassay for the quantification of soluble human semaphoring 4D in plasma.
Laber A et al., Anal Biochem, 2019; 574:15-22. Full publication.
Did you know?
Soluble Semaphorin 4D can easily be quantified with the Biomedica SEMA4D ELISA
√ HIGHLY SPECIFIC – antibodies bind with high affinities to conformational epitopes in the sema domain
√ ACCURATE – successful validation according to FDA guidelines
√ RELIABLE – 7 human plasma based standards and 2 controls for biologically reliable data
√ LOW SAMPLE VOLUME – only 10 µl / well required
√ Plasma is the suitable matrix for reproducible quantification of sSEMA4D