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Plasma NT-proCNP shows promise as a biomarker for sepsis-associated encephalopathy (SAE).
Sepsis-associated encephalopathy (SAE) has significant impact on the neurocognitive outcome of sepsis survivors. Biomarkers of brain injury and inflammation could help monitor encephalopathy in patients with sepsis.
Levels of NT-proCNP, a protein which is released during systemic inflammation, are highly elevated in both the plasma and CSF of sepsis patients with SAE. Since NT-proCNP levels in CSF and plasma NT-proCNP are highly correlated, plasma NT-proCNP might be a useful proxy biomarker to predict the emergence of SAE during the early phase of sepsis and detect neurological impairment at the later stages of the disease.
Plasma NT-proCNP measurement might be superior to S100B and NSE in SAE.
Ehler et al. Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy. Neurosci Lett. 2019;692:167-173.
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