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Effects of Vitamin D on Bone Markers in Kidney Disease
The process of aging is linked to physiological changes, which include a decline in bone mass and renal function. In a recent study, researchers investigated the effects of Vitamin D supplementation on bone metabolism and bone biomarkers in patients with and without renal impairment.
Effects of Vitamin D on Bone Markers in Kidney Disease
The study incorporated 379 patients with a mean age of > 70 years who were supplemented with various doses of vitamin D ranging from 12000 IU to 48,000 IU/month for a period of one year.
The biomarkers Sclerostin (SOST), Dickkopf-1 (DKK-1), Osteoprotegerin (OPG), and soluble RANKL (sRANKL) were measured with ELISA assays from BIOMEDICA.
Learn more: Early renal impairment affects hormonal regulators of calcium and bone metabolism and Wnt signalling and the response to vitamin D supplementation in healthy older adults. Christodoulou M et al., J Steroid Biochem Mol Biol. 2023. 229:106267. doi: 10.1016/j.jsbmb.2023.106267.
About the BIOMEDICA bone marker ELISA kits
Sclerostin (SOST) ELISA (BI-20492)
- Most referenced Sclerostin ELISA + 250 citations
- Low sample volume – 20µl / well
- Validated following international guidelines
Dickkopf-1 (DKK-1) ELISA (BI-20413)
- Widely cited + 170 publications
- Direct measurement
- Validated following international guidelines
Osteoprotegerin (OPG) ELISA (BI-20403)
- most referenced human OPG ELISA in +245 citations
- day test, ready to use color coded reagents
- controls included
Free soluble RANKL ELISA (BI-20462)
- Cited in over + 290 publications
FGF23 intact ELISA (BI-20700)
- for serum and plasma samples
- full validation data available
- citations
FGF23 c-terminal ELISA (BI-20702)
- for serum and plasma
- full validation data available
- + 43 citations
All assays are developed and manufactured by BIOMEDICA
Related publications
Fibroblast growth factor 23 (FGF23) and early chronic kidney disease in the elderly. Chudek J et al., Nephrol Dial Transplant. 2014 Sep;29(9):1757-63. doi: 10.1093/ndt/gfu063.
Effectiveness and safety of vitamin D in relation to bone health. Cranney A et al., Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. PMID: 18088161; PMCID: PMC4781354.