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C-Type Natriuretic Peptide: Emerging Applications in Disorders of Skeletal Growth
C-type natriuretic peptide (CNP), a small peptide hormone, plays a crucial role in linear growth. The growth plate is a major contributor to circulating CNP products in the immature skeleton. Its bio-inactive aminoterminal propeptide (NTproCNP) is easily measurable in plasma, and levels reflect the rate of CNP biosynthesis.
Plasma C-Type Natriuretic Peptide: Emerging Applications in Disorders of Skeletal Growth.
Espiner E et al.,Horm Res Paediatr,2019;7;90(6):345-357.
Did you know?
NT-proCNP can easily be quantified with the Biomedica 2nd generation NT-proCNP ELISA (cat.no. BI-20812)
√ HIGH SENSITIVITY – 0.7 pmol/l (= 3.49 pg/ml)
√ EASY – direct measurement – no concentration step
√ LOW SAMPLE VOLUME – only 20 µl / well required
√ ACCURATE – successful validation according to FDA guidelines
√ RELIABLE – 7 human plasma based standards and 2 controls for biologically reliable data
√ High cross-reactivity with rat NT-proCNP
Literature:
- Dynamic response of C-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short stature.
Olney RC et al.,Clin Endocrinol,2016;85(4):561-8. - Serum NT-proCNP levels increased after initiation of GH treatment in patients with achondroplasia/hypochondroplasia.
Kubota T et al.,Clin Endocrinol,2016;84(6):845-50. - Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.
Fujii T et al.,PloS One,2018;13(3):e0194812.