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IL-6 in exercise and health
It is well recognized that exercise has beneficial effects on overall health (1). Skeletal muscle has been described as a “secretory organ” that produces cytokines in response to muscle contraction (2). Thus, muscle communicates with various organs and tissues e.g. adipose tissue, liver, pancreas, bones, and brain (1).
IL-6 in exercise and health
Interleukin-6 (IL-6) is a cytokine that is primarily known to play a key role in inflammation and the regulation of the immune response. However, IL-6 is also an important signaling molecule during exercise. Numerous studies have demonstrated that Il-6 is produced locally in working skeletal muscle (3, 4). Exercise, in particular intense or prolonged physical activity increases circulating IL-6 levels contributing to the regulation of glucose and lipid metabolism (4). Additional effects of IL-6 are discussed in Exercise and health — emerging roles of IL-6.
- HIGHLY SENSITIVE – measurable values in serum and plasma samples
- EASY – ready to use calibrators and controls
- RELIABLE – full validation package
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- SMALL SAMPLE VOLUME – 10µl/well
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Angiopoietin-2 ELISA, cat. no. BI-ANG2
- Immediate results – assay range is optimized for clinical samples
- Characterized antibodies – detects all Angiopoietin-2 isoforms
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Mouse/Rat Angiopoietin-2 ELISA, cat. no. BI-ANG2MR
- Low sample volume- 5µl
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- Sample values provided
- Detects all Angiopoetin-2 isoforms
Literature
- Exercise and health — emerging roles of IL-6. Ellingsgaard H, Hojman P, Pedersen BK. Current Opinion in Physiology. 2019. 10; 49-54.
- The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review. Docherty, S., Harley, R., McAuley, J.J. et al. 2022. BMC Sports Sci Med Rehabil 14, 5.
- IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance. Nash D, Hughes MG, Butcher L, Aicheler R, Smith P, Cullen T, Webb R. Scand J Med Sci Sports. 2023. 33(1):4-19.
- Muscle-derived interleukin-6: possible biological effects. Pedersen BK, Steensberg A, Schjerling P. J Physiol. 2001. 15;536(Pt 2):329-37.