Interleukin-6 in Traumatic Brain Injury
Traumatic brain injury (TBI) is a sudden injury that causes damages to the brain. It is one of the most common causes of disability and death in adults (1). There are currently no early biomarkers for prognosis in routine clinical use (2). Apart from the initial injury, victims with TBI face the possibility of secondary neurological damage. Studies have identified TBI as a risk factor for all-cause dementia and Parkinson’s disease (3).
Interleukin-6 in Traumatic Brain Injury
Interleukin (IL)-6 is a proinflammatory cytokine that plays a key role in the immune response to acute neurological injury (1, 4) . Studies have shown that IL-6 may serve as a prognostic biomarker of clinical outcomes after traumatic brain injury (2).
IL-6 can reliably be measured with the highly sensitive IL-6 ELISA assay from Biomedica
IL-6 ELISA (Biomedica, cat. no. BI-IL6)
- HIGHLY SENSITIVE- measurable values in serum and plasma samples
- EASY – ready to use calibrators and controls
- RELIABLE – full validation package
Literature
- Interleukin-6 in Traumatic Brain Injury: A Janus-Faced Player in Damage and Repair. Ciryam P, Gerzanich V, Simard JM. J Neurotrauma. 2023 Nov;40(21-22):2249-2269. doi: 10.1089/neu.2023.0135. Epub 2023 Aug 10. PMID: 37166354; PMCID: PMC10649197.
- Interleukin-6 as a prognostic biomarker of clinical outcomes after traumatic brain injury: a systematic review. Ooi SZY, Spencer RJ, Hodgson M, Mehta S, Phillips NL, Preest G, Manivannan S, Wise MP, Galea J, Zaben M. Neurosurg Rev. 2022 Oct;45(5):3035-3054. doi: 10.1007/s10143-022-01827-y. Epub 2022 Jul 6. PMID: 35790656; PMCID: PMC9256073.
- Traumatic Brain Injury and Risk of Neurodegenerative Disorder. Brett BL, Gardner RC, Godbout J, Dams-O’Connor K, Keene CD. Biol Psychiatry. 2022 Mar 1;91(5):498-507. doi: 10.1016/j.biopsych.2021.05.025. Epub 2021 Jun 2. PMID: 34364650; PMCID: PMC8636548.
- Role of IL-6 in the regulation of neuronal development, survival and function. Kummer KK, Zeidler M, Kalpachidou T, Kress M. Cytokine. 2021 Aug;144:155582. doi: 10.1016/j.cyto.2021.155582. Epub 2021 May 29. PMID: 34058569.