Download biomedica product list
Novel Neuropilin-1 ELISA
Biomedica is happy to introduce our novel Neuropilin-1 ELISA that measures total human soluble NRP1 in biological samples utilizing specific EPITOPE MAPPED ANTIBODIES.
Assay Highlights:
- HIGHLY SPECIFIC and DEFINED – epitope mapped antibodies
- RELIABLE: human serum based calibrators and controls, rigorously validated
- LOW SAMPLE VOLUME: 10 µl / well
- QUICK: total incubation time 4 h
- PROTOCOLS available for urine, cc supernatants and non-human samples
Novel Neuropilin-1 ELISA
Areas of interest: neurological disorders, oncology, nephrology, osteology, cardiology
For detailed information please click corresponding links:
BI-20409 total soluble Neuropilin-1 product website
BI-20409 total soluble Neuropilin-1 ELISA IFU
BI-20409 total soluble Neuropilin-1 ELISA Validation Data
BI-20409 total soluble Neuropilin-1 ELISA MSDS
Biomedica ELISA Service Quotation Form
Related literature
Serum concentrations of neuropilin-1 in women with endometriosis. Barberic M, Pavicic Baldani D, Rogic D, Kralik S.Scand J Clin Lab Invest. 2020 Jul;80(4):271-276. doi: 10.1080/00365513.2020.1728785. Epub 2020 Feb 18. PMID: 32069143.
Abstract
Objective of this work is to investigate, for the first time, serum concentration of neuropilin-1 (NRP-1), aiming to evaluate its diagnostic performance in endometriosis and usability as a potential non-invasive serum marker of endometriosis. Two hundred women were treated laparoscopically. After laparoscopic surgery women were divided into two groups: 120 women diagnosed with endometriosis and 80 healthy women (control group). Blood samples were taken from all women undergoing laparoscopy half an hour before the induction of anesthesia, for the purpose of collection of serum. The level of NRP-1 in serum was assayed by a standardised sandwich enzyme-linked immunosorbent assay. Differences between endometriosis and healthy control group in NRP-1 levels were significant. All values were significantly and several times higher in patients group, p < .001. After receiver operating characteristic analysis, the area under curve was 0.97 (95% confidence interval: 0.941 to 0.989, p < .0001) at 11 µg/L cut-off level for NRP-1. Preliminary threshold values for NRP-1 in serum were assumed to serve as diagnostic parameters with sensitivity of 99.3% and specificity of 97.8%. Serum concentration of NRP-1 can be considered as a potentially good laboratory diagnostic, non-invasive marker for endometriosis.