NT-proBNP in end-stage kidney disease
Cardiovascular disease is the leading cause of death in patients with end-stage renal disease on dialysis (1). In an attempt to understand the underlying mechanisms of the high mortality among dialysis patients, other than the traditional cardiovascular risk factors, researchers investigated the association between gut permeability, circulating bacterial fragments, and volume overload in peritoneal dialysis (PD) patients (2).
Gut permeability, circulating bacterial fragments and measures of congestion in peritoneal dialysis.
In this prospective observational study, 108 consecutive adult incident PD patients were recruited and circulating bacterial fragments, N-terminal pro B-type natriuretic peptide (NT-proBNP), calprotectin and zonulin levels were evaluated (2).
NT-proBNP in end-stage kidney disease
Markers of fluid overload
NT-proBNP is recognized as a marker of marker of left ventricular strain and intravascular fluid overload (3, 4).
Fluid overload was quantified by serum levels of NT-proBNP with the Biomedica ELISA kit (Biomedica-cat. no. SK-1204) and with multi-frequency bioimpedance spectroscopy (2).
NT-proBNP ELISA assay kit (cat. no. SK-1204)
√ CE-marked – for IVD use in the EU
√ EASY – simple 2 step protocol, can be run in every lab
√ High and low kit controls included
√ RELIABLE – validated according to international quality guidelines (see validation data )
√ TRUSTED – widely cited in 125 publications
Example of a Biomedica ELISA Assay Kit
Literature
1. Cardiovascular complications in chronic kidney disease: a review from the European Renal and Cardiovascular Medicine Working Group of the European Renal Association. Zoccali C, Mallamaci F, Adamczak M, de Oliveira RB, Massy ZA, Sarafidis P, Agarwal R, Mark PB, Kotanko P, Ferro CJ, Wanner C, Burnier M, Vanholder R, Wiecek A. Cardiovasc Res. 2023 Sep 5;119(11):2017-2032. doi: 10.1093/cvr/cvad083. PMID: 37249051; PMCID: PMC10478756.
2. Gut permeability, circulating bacterial fragments and measures of congestion in peritoneal dialysis. Li C, Ng JK, Chan GC, Fung WW, Lai KB, Poon PY, Luk CC, Chow KM, Szeto CC. Clin Kidney J. 2024 Mar 6;17(3):sfae056. doi: 10.1093/ckj/sfae056. PMID: 38516523; PMCID: PMC10956420.
3. NT-proBNP, fluid volume overload and dialysis modality are independent predictors of mortality in ESRD patients. Paniagua R, Ventura MD, Avila-Díaz M, Hinojosa-Heredia H, Méndez-Durán A, Cueto-Manzano A, Cisneros A, Ramos A, Madonia-Juseino C, Belio-Caro F, García-Contreras F, Trinidad-Ramos P, Vázquez R, Ilabaca B, Alcántara G, Amato D. Nephrol Dial Transplant. 2010 Feb;25(2):551-7. doi: 10.1093/ndt/gfp395. Epub 2009 Aug 12. PMID: 19679559.
4. Determination of volume overload by bioelectrical impedance analysis and NT-proBNP in diabetic pre-dialysis patients. Acta Endocrinol (Buchar). Yildirim Y, Kara AV, Kilinç F, Aydin F, Aydin E, Yilmaz Z, Kadiroglu AK, Yilmaz ME. 2016 Jan-Mar;12(1):19-25. doi: 10.4183/aeb.2016.19. PMID: 31258795; PMCID: PMC6586753.