QUALITY CYTOKINE ELISA KITS

We are happy to introduce our new brochure featuring our Quality Cytokine Assays “BIOMEDICA´s CYTOKINE ELISA kits”  

Product Highlights

• Full validation package
• Ready-to-use prediluted standards
• Color coded reagents & controls included
• Kit calibration with WHO international standard

QUALITY CYTOKINE ELISA KITS FOR AFFORDABLE & EFFICIENT RESEARCH

human Cytokine ELISA Kits  – developed & manufactured by Biomedica

• IL-6 (cat. no. BI-IL6) –  high sensitivity – detectable levels
• VEGF (cat. no. BI-VEGF) –  low sample volume – 10 µl – detecting all known VEGF isoforms
• ANGIOPOIETIN-2 (cat. no. BI-ANG2)    / optimized assay range 

 

Also available mouse/rat Angiopoietin-2 ELISA kit (cat. no. BI-ANG2MR) –  only 5µl sample volume.

 

 

ABOUT CYTOKINES

Cytokines are critical cell signaling molecules that play important roles in the immune response and many other physiological processes.  These proteins are produced by a wide variety of cell types that act on specific target cell receptors to trigger a range of biological responses.

Cytokines are involved in many aspects of the immune response, including inflammation, cell growth and differentiation, and cell death (apoptosis). Cytokines also regulate tissue repair and wound healing. Dysregulation of cytokine production and signaling may contribute to various diseases including autoimmune disorders, allergies, and cancer.

Some common cytokines include interleukins, tumor necrosis factor (TNF), and interferons.

Interleukin-6 (IL-6) is a pleiotropic cytokine that is largely involved in immunomodulatory processes. One of its roles is to respond to infections. As a pro-inflammatory cytokine, IL-6 activates the immune response, recruiting immune cells triggering B and T cell response. IL-6 dysregulation is associated with pathologies involving chronic inflammation, autoimmune diseases, and atherosclerosis. However, IL-6 also has beneficial anti-inflammatory and positive metabolic effects that are released during exercise coupled to a physical adaptation to intense training. In addition to its immune functions, IL-6 is involved in many other physiological processes, including bone remodeling and the nervous system.

Angiopoietin-2 (ANG2) is a protein that plays a critical role in regulating the development and remodeling of blood vessels, a process known as angiogenesis. ANG-2 is primarily produced by endothelial cells, which are cells that line the interior of blood vessels. Under normal physiological conditions the expression of ANG2 is low, which allows the blood vessels to undergo a rapid growth and remodeling. However, in pathological conditions, such as inflammation and cancer, ANG2 expression can be upregulated, leading to excessive angiogenesis and blood vessel destabilization.

Vascular endothelial growth factor (VEGF) is a protein mainly produced by endothelial cells. VEGF stimulates the growth and proliferation of endothelial cells, as well as the migration and differentiation of these cells into new blood vessels. VEGF plays a role in the development of cancer and certain ocular diseases, where it promotes the growth of new blood vessels that feed tumors or damage the retina.

There are several different isoforms of VEGF, each with different properties and functions. For example, VEGF-A is the most well-known cytokine of the VEGF family, and is primarily responsible for promoting angiogenesis. Other isoforms, such as VEGF-B and VEGF-C, have different roles in the body, such as regulating the growth of blood vessels in the heart and lymphatic system, respectively.

Related publications

Harnessing cytokines and chemokines for cancer therapy. Propper DJ, Balkwill FR. Nat Rev Clin Oncol. 2022 Apr;19(4):237-253. doi: 10.1038/s41571-021-00588-9. Epub 2022 Jan 7. PMID: 34997230.

Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure. Hanna A, Frangogiannis NG. Cardiovasc Drugs Ther. 2020 Dec;34(6):849-863. doi: 10.1007/s10557-020-07071-0. Epub 2020 Sep 9. PMID: 32902739; PMCID: PMC7479403.