RANKL and RANK in extracellular vesicles: new players in bone remodeling
Extracellular vesicles (EVs) are cell-derived membranous structures that contain lipids, proteins, and nucleic acids of the source cell. They are released into the extracellular space and act as intercellular communicators. Receptor activator of NF-κB ligand RANKLL) and its receptor RANK are bone-cell derived key proteins that are crucial in regulating bone remodeling. EVs containing RANKL and RANK have recently been identified as intercellular regulators in bone biology and are attractive as drug targets and as biomarkers.
Read more Free soluble RANKL can reliably be measured by ELISA in serum and plasma.
Assay Highlights
• High sensitivity – measurable concentrations in healthy subjects
• Only ELISA that measures free, uncomplexed soluble RANKL
• CE marked – widely cited in clinical studies