Download biomedica product listMay is “Osteoporosis Month” raising awareness on bone health. Osteoporosis is estimated to affect 200 million people worldwide. Taking action for prevention, diagnosis and treatment can reduce the risk and the burden of osteoporosis.
Biomedica offers a wide range of bone biomarker ELISA kits for the accurate measurement of FGF23, Sclerostin, Osteoprotegerin, soluble RANKL, DKK-1, IL-6, and others.
Assay Highlights:
• EASY – ready to use calibrators & controls included
• RELIABLE – validated according to international quality guidelines
• WIDELY CITED in 1500 + publications
• COMPETENT CUSTOMER SERVICE
Complete ready-to-use ELISA kits for superior performance and reproducibility: https://buff.ly/2N3xY97
Recent advancements in genetic #research have uncovered new forms of monogenic #osteoporosis. Mutations in WNT1, encoding a WNT/β-catenin pathway ligand WNT1, and PLS3, encoding X chromosomally inherited plastin 3 (PLS3), both result in early-onset osteoporosis with prevalent fractures and disrupted bone metabolism.
Data from a study by Mäkitie RE et al. indicate a link between PLS3 and DKK1 and WNT1 and FGF23 in bone metabolism (measured with biomedica kits). Therefore, DKK1 and FGF23 may be clinically useful biomarkers for PLS3 and WNT1 osteoporosis, respectively.
Check out the Biomedica DKK-1 and FGF23 ELISA kits:
– Reliable – validated according to international guidelines
– Specific – epitope mapped antibodies
– CE marked – widely cited in clinical studies
Biomarkers in WNT1 and PLS3 Osteoporosis: Altered Concentrations of DKK1 and FGF23 . Mäkitie RE et al., J Bone Miner Res, 2020 May;35(5):901-912.
Researchers identified the soluble bone metabolism biomarker DKK-1 to be independently associated with future cardiovascular events, which are primarily driven by increased risk of stroke.
Associations of Serum Dickkopf‐1 and Sclerostin With Cardiovascular Events: Results From the Prospective Bruneck Study.
Klingenschmid G et al., JAHA 2020; Mar 17;9(6):e014816.
Serum DKK-1 can easily be measured by ELISA assay
√ SIMPLE analysis – direct measurement – results in 3.5 h
√ LOW SAMPLE VOLUME – only 20µl sample / well
√ HIGH QUALITY Assay – fully validated
√ WIDELY USED – >100 citations
√ CE marked – for IVD use in EU!
Interested in performing a study? Contact us for your special offer :
e-mail, or phone: +43-1-29107-45.